(Head of Laboratory)
(Associate Professor, Collaborator)
(undergraduate project student)
Aquaporins (AQPs) are small transmembrane proteins (26–34 kDa) that were initially thought to function only as bidirectional water-selective channels, they have successively been found to play a role in important cellular functions, such as cell proliferation, cell differentiation, cell migration and cell adhesion.
Current laboratory lines of investigation:
(i) aquaglyceroporins functions and regulation in human white adipose tissue: implication in obesity and type-2 diabetes.
(ii) Aquaporin-8 transport of hydrogen peroxide regulation of cell signaling, proliferation and survival.
Selected PapersMammalian aquaglyceroporin function in metabolism. Laforenza U, Bottino C, Gastaldi G.Biochim Biophys Acta. 2016 Jan;1858(1):1-11. doi: 10.1016/j.bbamem.2015.10.004.
Aquaporin-10 represents an alternative pathway for glycerol efflux from human adipocytes. Laforenza U, Scaffino MF, Gastaldi G. PLoS One. 2013;8(1):e54474. doi: 10.1371/journal.pone.0054474.
Water channel proteins in the gastrointestinal tract. Laforenza U. Mol Aspects Med. 2012 Oct-Dec;33(5-6):642-50. doi: 10.1016/j.mam.2012.03.001.