Projects 2022/23

Projects 2022/23

The PhD Programme in Translational Medicine has now reached its 5th year of activity. The programme has expanded year after year and now offers projects that span research in Biochemistry, Cellular and Human Physiology, Immunology, Cancer Biology, Gastroenterology, Hepatology, Cardiology and Haematology. A poster displaying the area of activity of the Programme is available at this page.

The PhD Programme in Translational Medicine has been greatly strengthened by the recent availability of core equipment (NMR spectroscopy, cryo-electron microscopy, super resolution microscopy, cell sorting, micro computed tomography, pre-clinical magnetic resonance imaging, mass spectrometry and a high performance computer cluster.  This equipment is fully available to research students enrolling in the PhD Programme in Translational Medicine and much of is located in a central facility close to the main departmental buildings (Centro Grandi Strumenti).

The text below provides a list of the 13 projects available for the three year cycle starting on 1st October 2021. Interested students can contact Enza Maria Valente, coordinator of the PhD Programme in Translational Medicine for general questions concerning the admission procedure.  They can also  contact the supervisors of individual projects in order to seek additional information about each project.

List of Projects 2022/23

01. Monica Canepari
Exercise performance and gender differences – the role of individual muscle fibers properties

02. Ornella Cazzalini
Studying interactions between proteins involved in cell cycle regulation and DNA replication and repair

03. Lia Crotti
Novel pharmacological strategies for the treatment of the Long QT Syndrome

04. Antonio di Sabatino
Inflammation and Cancer: histologic and molecular studies of precancerous changes in coeliac and Crohn’s disease

05. Christina Kiel
Computational energy supply and demand model of the aging human outer retina

06. Umberto Laforenza
Aquaporins in tumor cells: regulatory mechanisms from intracellular to nanotubes and microvesicles passing through the plasma membrane

07. Konstantinos Lefkimmiatis
Title of the research project: Unravelling the code of mitochondrial-nuclear communication

08. Marco Lolicato and Cristina Arigoni
The KCC2 interactome: A structural approach to provide mechanistic understanding of GABAergic inhibition and therapeutic venues for neurodevelopmental disorders

09. Mario Mondelli
A multidisciplinary approach to identify biomarkers of Post-Acute Sequelae of SARS-CoV-2 infection

10. Mario Nuvolone
Dissecting the pathogenic role of N-glycosylation in AL amyloidosis: molecular bases, diagnosis, and treatment

11. Carla Olivieri
Cryptic Pathogenic Variants in Hereditary Haemorrhagic Telangiectasia: a Whole Genome Sequencing approach

12. Arianna Palladini
Vaccines to overcome Therapeutic Resistance in Lung Cancer

13. Giovanni Palladini
Promoting Diagnosis and management of AL in Italy

14. Maria Antonietta Pellegrino
Fibro-adipogenic precursors (FAPs): novel players in muscle plasticity

15. Roberto Pizzala and Paola Perin
Neurogenesis, immunity, and inflammation in the auditory system

16. Monica Savio
Cellular and molecular mechanisms of resveratrol derivatives against cancer development

17. Claudia Scotti
Structural basis of antibody affinity maturation

18. Virginie Sottile
Developing cancer stem cell differentiation models using 3D organoids to potentiate oncotherapies

19 Enza Maria Valente
Functional characterization of a novel gene implicated in neurodevelopment

20. Enza Maria Valente
Characterization of a novel mitochondrial function of PINK1 in Parkinson disease pathogenesis|

21. Alessandra Balduini
Bone marrow modeling for platelet production

22. Christian di Buduo
Calcium signaling networks in physiological and pathological megakaryopoiesis

23. Massimiliano Gnecchi
Use of induced pluripotent stem cells for the study of ion channel heart disease

24. Marco Lolicato
Development of miniaturized technologies for the development and electrophysiological validation of novel molecules on ion channels and transporters involved in orphan cancer or neurodevelopmental disorders

25. Virginie Sottile
Development of 2D & 3D culture models of neurogenesis using patient-derived stem cells to study neurodevelopmental diseases


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