Faculty & Supervisors

Faculty & Supervisors

University Faculty

A total of 19 staff members of the University of Pavia have joined the Faculty of the new, department-let PhD Programme in Translational Medicine.  From October 1, 2017 these  include 14 members of the Department of Molecular Medicine, 1  member of the University of Milano-Bicocca and 2 members of the Department of Internal Medicine (Antonio di Sabatino and Mario Mondelli).  Collectively the core Faculty of the PhD Programme cover a range of research programmes ranging from the study of the structural basis of disease and disease mechanisms in experimental models such as transgenic or knocck-out mice, the search of new disease biomarkers, clinico/laboratory investigations in the areas of infectious, heart and blood diseases and drug discovery programmes, both small molecules and biologicals.   A list of the Faculty members active in the PhD Programme of Translational Medicine, together with an outline of their activities, is given below in order to offer students ready access to the scientific profiles of their prospective supervisors.


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Alessandra Balduini, Associate Professor of Laboratory Medicine, University of Pavia.

Research Interests: Bone marrow microenvironment in the regulation of peripheral blood cell formation and diseases. The role of calcium in the regulation of platelet production from megakaryocytes. Extracellular matrice and megaKaryocytopoiesis. 3D bone marrow modelling for platelet production, mechanisms of disease and drug testing. Silk based biomaterials.

Funding: Italian Ministry for Education, University and research, Cariplo Foundation, European Community, AIRC, Telethon

Further Roles: Member of the PhD programme in Translation Medicine


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Roberto Bottinelli, Prof of Physiology and Group Leader, University of Pavia.

Research Interests: Development and regeneration of skeletal muscle. Molecular basis of contraction. Mouse models of muscular hypertrophy and hypotrophy. Cell therapy for muscular diseases.

Funding: Italian Ministry for Education, University and Research, Cariplo Foundation

Further Roles: Deputy Chancellor for Research, Un of Pavia.


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Mario Cazzola, Prof of Haematology and Group Leader, University of Pavia, until 30th September 2017

Research Interests: Genetic basis of myeloid malignancies and its clinical relevance. Development of precision medicine strategies for hematologic malignancies.

Funding: Associazione Italiana per la Ricerca sul Cancro (AIRC), Fondazione Regionale per la Ricerca Biomedica (FRRB).

Further Roles: Associate Editor, Blood, j of the Amer Society of Hematology (ASH); Chair, Scientific Working Group Precision Medicine of the Eur Hematology Ass (EHA).


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Lia Crotti, Professor of Cardiology, University of Milano – Bicocca, since 1th October 2017 .

Research Interests: genetic basis of sudden cardiac death, in genetically transmitted arrhythmogenic diseases (channelopathies and cardiomyopathies), in the Sudden Infant Death Syndrome (SIDS), stillbirths and in more common diseases, such as myocardial infarction.

Funding: Italian Ministry for Education, University and Research, Horizon 2020

Further Roles: Member of the PhD programme in Translational Medicine, University of Pavia.


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Cesare Danesino, Prof of Medical Genetics, University of Pavia.

Research Interests: Study of genotype-phenotype correlation in rare diseases, study of thei pathogenic mechanisms, identification of modifier genes, use of genetic data in counselin and preanatal diagnosis

Funding: Charities related to several  rare disease (AIG, AISS, HHT-onlus), University of Pavia, private companies (Sanofi)

Further Roles: Deputy Director of Molecular Medicine Department, University of Pavia


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Gaetano De Ferrari, Prof of Cardiology and Group Leader, Un of Pavia.

Research Interests: Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo.

Funding: Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod

Further Roles: Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do


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Antonio Di Sabatino, Professor of Internal Medicine, University of Pavia.

Research Interests: Molecular basis of gastrointestinal inflammation, mechanisms of oral tolerance, traslational approaches for inflammatory bowel disease and coeliac disease, splenic hypofunction.

Funding: University of Pavia, San Matteo Hospital Foundation, Associazione Italiana Celiachia.
Further Roles: Honorary Senior Lecturer, Department of Medicine, University College London (UCL) London (UK)


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Monica Galliano, Prof of Biochemistry and Group Leader, Un of Pavia.

Research Interests: Structural and functional characterization of proteins; Lectins; mutations of the Human Serum Albumin gene.

Funding: Italian Ministry for Education, University and Research.

Further Roles: Dean of the Course in Medicine and Surgery (English), University of Pavia.


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Ermanno Gherardi, Prof of General Pathology and Group Leader, University of Pavia.

Research Interests: Cell beahviour: growth and migration, cancer cell biology, regenerative medicine, antibody engineering,

Funding: Arisla, Associazione Italiana per la lotta a Leucemia e Linfomi, Industry

Further Roles: Director of the Department of Molecular Medicine, University of Pavia, Director Collegio A Volta, University of Pavia



Massimiliano Gnecchi, Assistant Professor of Cardiology, University of Pavia.

Research Interests: Ischemicheat. Cell therapy for heart disease. Regenerative medicine. IPSC for cardiac disease modelling. Role of microRNA in heart disease.

Funding: Italian Ministry for Education, Italian Ministry of Health

Further Roles: Member of the PhD programme in Translation Medicine -University of Pavia. Chair of the Cardiovascular Committee of the international Society of Cell Therapy


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Giampaolo Merlini, Prof of Clinical Biochemistry and Group Leader, Un of Pavia.

Research Interests: Pathogenesis, natural history, diagnosis, and treatment of monoclonal gammopathies and systemic amyloidosis

Funding: Italian Ministry of Health, Cariplo Foundation, Italian Association for Cancer Research (AIRC), Telethon, European Commission (E-Rare)

Further Roles: Scientific Director, Foundation IRCCS Policlinico San Matteo, Pavia


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Mario Mondelli, Prof of Virology and Group Leader, Un of Pavia.

Research Interests: Acute and chronic liver disease. Immune response to hepatitis viruses. Innate immunity. Natural killer cells. Tumor immunology and  immunotherapy. Viral hepatitis and autoimmune liver disease.

Funding: Italian Ministry for Education, University and Research, Ministry of Health, Regione Lombardia

Further Roles: Deputy Scientific Director, Fondazione IRCCS Policlinico San Matteo. Editor-in-Chief, Liver International. President, Viral Hepatitis Group, Eur Soc for Clinical Microbiology and Infectious Diseases (ESCMID)


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Giovanni Palladini, Prof of Clinical Biochemistry and Group Leader, Un of Pavia.

Research Interests: Biomarker-based diagnosis, prognostic stratification and monitoring of systemic amyloidosis. Therapy of AL amyloidosis.

Funding: ERA-Net for Research Programmes on Rare Diseases, Cariplo Foundation, International Myeloma Sciety

Further Roles: Acting Director, Laboratory for Biochemistry, Biotechnology and Advanced Diagnostics and Center for Amyloidosis Research and Treatment, Foundation IRCCS Policlinico San Matteo, Pavia


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Annalisa Pastore, Prof of Clinical Biochemistry and Group Leader, Un of Pavia.

Research Interests: Structural Biology and Biophysics of Neurodegeneration. Mitochondrial diseases. Iron-sulfur cluster biogenesis. Protein folding and stability

Funding: UK Medical Research Council

Further Roles: Panel member Swedish Ministry of Research and Education and German Research Foundation (DFG). Chief Editor: Open Systems Biology Journal and Frontiers in Biosciences. Editorial board member: J Biol Chem, PlosOne, Medicinal Chemistry, Prion, ScienceJet, PeerJournal, The Open Biochemistry Journal and The Open Spectroscopy Journal


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Maria Antonietta Pellegrino, Professor of Physiology, University of Pavia

Research Interests: Molecular mechanisms of muscle plasticity

Funding: AFMTelethon

Further Roles: Member of the PhD programme in Translational Medicine, University of Pavia.

 


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Elisa Rumi, Prof of Haematology and Group Leader, Un of Pavia.

Research Interests: Diagnosis, prognosis and therapy of myeloproliferative neoplasms with special interest for familial cases.

Funding: Associazione italiana per la ricerca sul cancro (AIRC)

Further Roles: Principal investigator and subinvestigator in sponsored and non-sponsored trials in patients with myeloproliferative neoplasms


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Enza Maria Valente, Professor of Medical Genetics and Group Leader, Un of Pavia.

Research Interests: Development and wiring of the central nervous system. Molecular basis of neuronal differentiation.  Mouse models of genetic diseases of the brain.  Genetic basis of cognition.

Funding: European Commission, Italian Ministry for Health, Telethon

Further Roles: PhD Programme Coordinator, Translational Medicine,  Un of Pavia.



Livia Visai, Prof of Biochemistry and Group Leader, Un of Pavia.

Research Interests: Nanotechnology for tissue regeneration, nanomedicine and infection control

Funding: Italian Space Agency (ASI), Crowdfunding Platform (University of Pavia), Industry

Further Roles: Member of the Center for Health Technologies, University of Pavia; Scientific Committee of the European Center for Nanomedicine (CEN), Scientific Committee of the Italian Society for Biomaterials; (SIB). Type A Researcher at INSTM, Inter-university Consortium of Materials Science and Technology. Type A Researcher at INSTM, Inter-university Consortium of Materials Science and Technology.


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External Faculty

A distinctive feature of the PhD Programme in Translational Medicine – arguably a unique feature for a PhD Prgramme rooted in an Italian University, is the international character of the Programme. This is reflected in the effort that the Programme has undertaken to recruit students from abroad and by a major involvment of international scientists in the advisory board of the PhD Programme working at Universities (Oxford, Cambridge, Amsterdam, Zurich, Karolinska, Utah, Yale, Harvard, MIT) and Research Institutes (German Cancer Research Institute, Ludwig Cancer Institute, Dana Farber Cancer Institute). Further, the Programme is committed to involve Research Institutes active in Italy in order to develop the Programme as both a national and international enterprise.  Two Italian Research Institutes (CNR and RiMED) have been involved from start, namely from 2017/18.  Negotiations are in progress with several other Research Institutes with the view to includethem in the Programme from the academic year 2018/19.


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Liana Veneziano, Prof of Clinical Biochemistry and Group Leader, Un of Pavia.

Research Interests: Neurogenetics, Huntington disease, molecular basis of hereditary ataxias (spinocerebellar ataxias and episodic ataxias).

Funding: National Ataxia Foundation (NAF), National Research Council of Italy (CNR)

Further Roles: Member of the PhD programme in Translational Medicine, University of Pavia.


Other Supervisors

In addition to the 14 members of the Department of Molecular Medicine who act as Faculty of the PhD Programme in Translational Medicine a further 13 members of the Department have agreed to take a role in the Programme and the majority of them has offered projects. These staff members therefore act as independent and lead project supervisors and their projects are offered to prospective students alongside the projects offered by Faculty members.  if the students who are offered awards choose any of these projects. Thus they are full and equal members of the Programme alongside Faculty members.

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Paolo Bernasconi, Prof of Haematology and Group Leader, Un of Pavia.

Research Interests: Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo.

Funding: Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod

Further Roles: Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do


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Lorenza Brocca, Research Staff in Physiology, Un of Pavia.

Research Interests: Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo.

Funding: Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod

Further Roles: Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do


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Monica Canepari, Professor of Physiology, University of Pavia.

Research Interests: Molecular basic of contraction. Nerve-muscle interctio. Mouse and Human models of muscular atrophy.

Funding: Italian Ministry for Education, University and Research, Blue Sky Research

Further Roles: None


 

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Hugo de Jonge, Research Staff in General Pathology, University of Pavia and member of the Cancer Research Centre (CRC) in Pavia.

Research Interests:  Hepatocyte Growth Factor/Scatter Factor induced receptor activation of the tyrosine kinase receptor c-Met in Cancer and the development of potent antagonistic and agonistic molecules for the application in cancer and regenerative medicine respectively, using protein engineering, monoclonal antibody technology and structural biology.
Funding:  None
Further Roles: Laboratory management, student supervision and lecturing first year Harvey medicine course “Essay Writing Techniques” and third year “Precision Medicine”.


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Giulia Gastaldi, Prof of Physiology and Group Leader, Un of Pavia.

Research Interests: Adipose stem cells utilization in tissue engineering for osteoarticular disease. Role of aquaglyceroporins in hydrogen peroxide cellular cleavage

Funding: Collaborative research agreements with industrial partners

Further Roles: Member of the Centre for Health Technologies (CHT)


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Umberto Laforenza, Prof of Physiology and Group Leader, Un of Pavia.

Research Interests: Aquaporins functions in different cells and tissues. Store operated calcium channels expression and functions in normal endothelial cells and in cancer.

Funding: none

Further Roles: Dean of the MSc Course in Medical and Pharmaceutical Biotechnology, University of Pavia.


Alessandro Malara, Group Leader, Un of Pavia.

Research Interests: Bone marrow microenvironment in hematopoietic homeostasis and diseases

Funding: Italian Ministry for Education, University and Research

Further Roles: Member of the PhD programme in Translational Medicine, University of Pavia.


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Lorenzo Minchiotti, Prof of Biochemistry and Group Leader, Un of Pavia.

Research Interests: Human serum albumin: structure and function, genetic variants, molecular diagnosis and molecular genetics of analbuminaemia

Funding: 

Further Roles: Coordinator of year 1 of the Course in Medicine & Surgery (Golgi Course).


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Antonella Minelli, Researcher, Medical Genetics, University of Pavia.

Research Interests: molecular studies on Shwachman-Diamond Syndrome, including 1. mutation analysis of  SBDS gene, 2. study of clonal chromosome abnormalities by genotyping approach in bone marrow  and in cells separated from  peripheral blood, 3. studies  of genomic and clinical variations in Shwachman-Diamond Syndrome

Funding: shwachman-Diamond Syndrome Italian Research Grant from Associazione Italiana Sindrome di Shwachman (AISS)
Further Roles: Member of the PhD programme in Translational Medicine, University of Pavia.


 
Mario Nuvolone, Assistant Professor in Clinical Chemistry, University of Pavia.

Research Interests: Systemic amyloidoses. Prion diseases. Mouse models of protein misfolding and deposition diseases. Biomarkers.

Funding: Synapsis foundation

Further Roles:Member of the PhD programme in Translational Medicine, University of Pavia.


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Carla Olivieri, Researcher in Applied Biology, DMM, General Biology and Medical Genetics Units, University of Pavia

Research Interests: mutation analyses in Hereditary Hemorrhagic Telangiectasia (HHT).

Funding: Italian HHT charity: Fondazione Italiana per la Teleangiectasia Emorragica Ereditaria.

Further Roles: member of the joint committee of Master Degree in Medical and Phamaceutical Biotechnologies.


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Roberto Pizzala, Prof of General Pathology and Group Leader, Un of Pavia.

Research Interests: Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo.

Funding: Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod

Further Roles: Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do


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Elena Rossi, Prof of Medical Genetics and Group Leader, Un of Pavia.

Research Interests: Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo.

Funding: Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod

Further Roles: Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do


 
Claudia Scotti, Researcher, University of Pavia.

Research Interests: Molecular basis of physiology and disease. Antibody structure and engineering. Asparaginase engineering. Leukaemia. Lipoprotein(a) related diseases pathogenesis

Funding: Regione Lombardia – Cariplo Foundation

Further Roles: Member of the PhD programme in Translational Medicine, University of Pavia.

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