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Role of Tumour Associated Macrophages in Metastasis of Colorectal Carcinoma

Event Details:

  • Date: - -
  • Venue: Online
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On Tuesday the 22nd of September 2020 Ji-Liang Li of Plymouth University Peninsula School of Medicine will give a seminar entitled Role of Tumour Associated Macrophages in Metastasis of Colorectal Carcinoma. The seminar is open to members of the Department, other academic staff, students and members of Collegio A Volta and will be delivered online. The link for access is available on the poster that can be downloaded here.

Abstract
Colorectal carcinoma (CRC) remains a leading cause of cancer-related mortality due to metastasis. Metastasis is initiated by genetic alteration, epithelial-mesenchymal transition (EMT), cell protrusion, invasion and migration of tumour cells orchestrated by stromal cells in tumour microenvironment. Precise functions of tumour-associated macrophages (TAMs) in metastasis and clinical significance in CRC are still unclear. In this seminar, Professor Li presents substantial evidences demonstrating that TAMs present at tumour invasive edge are dominated by M2-like macrophages and secrete numerous proteins. Galectin-1, an abundant secreted protein, binds to the myosin 1b (MYO1B)-containing membrane-associated protein complex on neighbouring tumour cells at tumour invasive front, triggers EMT and cytoskeleton reorganization, induces filopodial and invadopodial formation, and consequently drives migration and invasion of tumour cells via paracrine galectin-1-MYO1B-RACK1 signalling. Blockade of the pathway at each step abolishes all downstream effects. Collectively, the results clarify the role of TAMs in CRC metastasis and suggest targeting M2-like TAMs particularly galectin-1-MYO1B-RACK1 signalling may represent novel therapeutic strategies against CRC.

Biography
Dr Ji-Liang Li became a full professor and chair at Institute of Translational and Stratified Medicine, Plymouth University Peninsula School of Medicine UK in 2015 and an honorary professor and director of Cancer Research Centre, University of Chinese Academy of Science Wenzhou Institute China in 2019. He studied Medicine and received his postgraduate training with Master of Medicine. He has studied for his PhD in London University London School of Hygiene and Tropical Medicine (1992-1996) and experienced as Postdoctoral Research Associate in Department of Biochemistry at University of Oxford (1996-1999), Senior Research Fellow at Imperial Cancer Research Fund (1999-2002), Tenured Staff Scientist/Deputy Lab Head in Cancer Research UK (2002-2007), and Tenured Scientist/Deputy Lab Head in Weatherall Institute of Molecular Medicine at University of Oxford (2007-2015) prior to working at Plymouth University as a Professor and Chair in Cancer Immunology. He has published >80 scientific papers, with >9350 citations and a h-index of 48 (Google Scholar). He has served as an editorial board member for a dozen of international journals. His current research interests are focused on tumour microenvironment and translational cancer medicine.

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